In addition to weight loss, semaglutide can lead to greater reductions in waist circumference, systolic and diastolic blood pressures, HbA1c, fasting plasma glucose, and fasting cholesterol levels.

Research is ongoing into other beneficial properties of GLP-1 medications. Improvements and protection of the heart, kidneys, and other organ systems are being actively investigated. Studies are also being conducted on the potential for GLP-1 medications for treatment of addictive disorders.